Regain Control Over Alcohol with the Sinclair Method
A research-based alcohol reduction treatment using the medication naltrexone
What is the Sinclair Method?
The Sinclair Method (TSM) is a proven, science-backed approach to treating alcohol use disorder. It involves naltrexone, a medication taken before drinking to block the release of endorphins triggered by alcohol. Over time, TSM helps retrain the brain, leading to fewer alcohol cravings, more effortless alcohol-free days, and greater control over drinking habits.
Key Benefits of the Sinclair Method
TSM is a powerful solution for those who want to regain control and moderate their drinking, offering a stress-free, sustainable approach without the pressure to quit entirely.
Is the Sinclair Method Right for Me?
This 15-minute video provides a clear overview of the treatment, detailing who can benefit from it and who it may not be suitable for.
How the Sinclair Method Works
According to Dr David Sinclair's research, the Sinclair Method harnesses the power of naltrexone, a medication that blocks the release of endorphins—the chemical rewards in the brain triggered by drinking alcohol.
Endorphin Blocking
The Sinclair Method uses naltrexone, a medication that blocks the release of endorphins—chemical rewards in the brain triggered by drinking alcohol.
Interrupting the Cycle
Taking naltrexone an hour before drinking prevents these endorphins from creating the pleasurable "buzz" that reinforces habitual drinking.
Rewiring the Brain
Over time, this process helps your brain “unlearn” the connection between alcohol and pleasure, gradually reducing cravings and the compulsion to drink.
Learn more about how our program has helped people just like you sustainably change drinking habits using the Sinclair Method
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Step-by-Step Process of the Sinclair Method
Curious about how to do the Sinclair Method protocol? Here’s how this simple yet effective protocol is done, based on Dr. David Sinclair’s groundbreaking research
Take Naltrexone Before Drinking 💊
Naltrexone is taken one hour before alcohol consumption to allow the medication to block endorphins, the brain’s chemical rewards associated with drinking.
Drink as Usual 🍷
While drinking with naltrexone in effect, the lack of endorphin reinforcement gradually reduces the brain’s learned connection between alcohol and pleasure, leading to a natural decline in cravings over time.
Regain Control 💪
As cravings diminish, individuals following this protocol often experience greater ease in reducing their alcohol consumption, managing alcohol-free days, or achieving moderation, depending on their goals.
Meeting the Medication Halfway
1. 💊 Take the Medication Consistently
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Always take naltrexone as prescribed before drinking.
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Establish a routine to help the medication work effectively.
2. 📉 Track Your Progress
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Keep a drink log to notice patterns and progress over time.
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Reflect on changes in your cravings and drinking habits.
3. 💆 Explore New Coping Strategies
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Find activities that help you unwind or bring joy without relying on alcohol.
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Start small by incorporating one new healthy habit at a time.
4. 📆 Be Patient and Stay Committed
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TSM is a gradual process, not a quick fix.
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Celebrate small wins and don’t let setbacks discourage you.
By partnering with the medication in this way, you can make real progress and regain control over your relationship with alcohol. At Thrive, we specialize in this. 😎
Sinclair Method FAQs
What else do I do besides take the medication?
How long does it take to work?
How do I get started on the Sinclair Method?
Do I have to quit drinking on the Sinclair Method?
What are the side effects of naltrexone?
What is naltrexone?
Thrive's Sinclair Method Resources & Support
Discover the comprehensive resources and expert support offered by Thrive, a program dedicated to helping individuals succeed with the Sinclair Method.
Sinclair Method Program
Private and 100% online. Specialized Sinclair Method support on your schedule at your pace.
Naltrexone Referral
Upon joining, you’ll receive a referral to a specialist physician for a personalized medication consultation.
Sinclair Method Coaching
Thrive offers personalized coaching options, with a TSM coach always just a click away. Choose group sessions, one-on-one support, or a mix of both.
Sinclair Method Support Groups
Join one of our weekly group calls or workshops to receive tailored TSM support—or simply listen in and learn at your own pace.
Sinclair Method Video Lessons
Learn the Sinclair Method with our library of over 50 step-by-step video lessons, designed to guide you and help transform your drinking at your own pace.
Sinclair Method Community
Join our private, judgment-free community, accessible anytime via web or mobile app. Connect with peers on the same TSM journey and get support from experienced coaches.
Sinclair Method Success Stories
Discover inspiring stories from real people who've struggled with alcohol issues and overcome them with this powerful approach
Ready to try it for yourself?
Research Shows Naltrexone Works Best When Combined With Support
Dr. Joseph Volpicelli, leading naltrexone
expert researcher and physician explains the importance of support alongside medication therapy for alcohol use disorder.
And that's why our program delivers personalized guidance to you at your own pace. 🤗
"I support The Sinclair Method because all throughout my psychiatric residency training, alcohol treatment was very all or none in regards to AA and abstinence or using medications like Antabuse or Campral, with essentially expected poor outcomes. When I learned about The Sinclair Method, it was a lightbulb moment, and I saw immediate life-changing responses with my patients. I have been a believer since then, as this has been the only treatment where I have seen consistent and sustained positive results. It is a game-change and a life-saver."
Sulman Aziz Mirza, MD
Triple Board Certified Psychiatrist, LouCouPsych
Since 2018, we have helped hundreds of people gain control over alcohol using The Sinclair Method.
Will you be next?
Explore the Sinclair Method with Expert Guidance
Learn about the physician-recommended support program for targeted use of naltrexone, commonly referred to as The Sinclair Method
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