• Naltrexone has been approved by the FDA for treatment of alcohol use disorder since 1994.
• Naltrexone is considered a safe, non-addictive and non-habit-forming medication that has very few interactions or side effects for most people.
• Following The Sinclair Method, naltrexone works by blocking the endorphin reward from alcohol. It does not make a person sick from alcohol like Antabuse.
• A prescription is required in most parts of the world for naltrexone.
• If you're not working with a doctor yet, when you join the Program, we'll connect you with a telemedicine physician who can consult and monitor your prescription. 👍

According to SAMHSA.gov, these are the most common naltrexone side effects:

• nausea
• sleepiness
• headache
• dizziness
• vomiting
• decreased appetite
• painful joints
• muscle cramps
• cold symptoms
• trouble sleeping
• toothache

According to Medical News Today, most side effects go away as the body adjust to naltrexone.

When you join Thrive, we’ll connect you with a specialized doctor who focuses on prescribing naltrexone and helping patients get started with confidence. These doctors are experienced in tailoring the treatment to minimize side effects, ensuring a smooth and supportive start to your journey.

For more details on naltrexone side effects, check out this video and blog with our medical advisor, Dr. Joseph Volpicelli

At Thrive, we often call it "meeting the medicine halfway." While naltrexone is a powerful tool in helping to heal the brain and reduce cravings, the real transformation happens when you pair it with intentional action, habit changes, and support. That’s where Thrive comes in—we’re here to help you meet the medicine halfway and achieve lasting success.

• Track Your Progress with Clarity: Our tools make it easy to log your drinking, cravings, and alcohol-free days, helping you see your progress and stay on track.
• Master Mindful Drinking: We’ll teach you techniques to slow down, drink intentionally, and better understand your relationship with alcohol.
• Set and Achieve Goals: Whether it’s drinking less, having more alcohol-free days, or long-term lifestyle changes, we’ll help you set realistic, personalized goals.
• Create New Habits: Thrive helps you replace old drinking routines with healthier, more fulfilling activities that align with the life you want to create.
• Develop Coping Strategies: We provide guidance to help you manage stress, emotions, and triggers without relying on alcohol.
• Learn Through Expert Education: Gain a clear understanding of how naltrexone works and how to maximize its effectiveness with our easy-to-follow resources.
• Be Part of a Supportive Community: Join a group of people who understand your journey and get personalized coaching from experts who have been where you are.
• Celebrate Every Step Forward: We’re here to acknowledge your wins—big and small—and remind you that progress is always worth celebrating.

Thrive is created by people with firsthand experience with Alcohol Use Disorder (AUD) and naltrexone, specifically for those ready to take an active role in their journey. By meeting the medicine halfway with our expert guidance and unwavering support, you can create lasting change and regain control of your drinking for good. Join us today!

You can get started today by choosing a membership option here.

• Choose Your Plan. Visit our plan page to select the level of support that best fits your needs for alcohol reduction using the Sinclair Method.

• Gain Instant Access. Once enrolled, instantly access our private program featuring video lessons, resources, and peer and coaching support.

• Start Your Journey. Get a Naltrexone referral if needed and use our tools, coaches and community to follow TSM correctly and reduce your drinking at your own pace.

The timeframe for success with naltrexone varies for everyone, and that’s perfectly normal! Here’s what to expect:

• Average Timeline: Most people achieve their drinking goals—whether moderation or abstinence—within 9 months to a year.
• Faster Results: Some see significant progress in as little as 3 months.
• Longer Timelines: Others may take up to 3 years to reach their goals.
• Shifting Focus: Once cravings are reduced, the focus shifts to addressing habits, routines, and coping mechanisms tied to drinking.
• Time and Patience: These lifestyle changes are a crucial part of transforming your relationship with alcohol, and they take time to develop.

At Thrive, we’re here to guide and support you every step of the way. Our program is designed to help you navigate this journey, make meaningful progress, and create lasting change—all at your own pace.

Yes, naltrexone is considered safe when prescribed by a doctor. It is non-addictive and has been extensively researched for use in treating AUD. Before you start naltrexone, your doctor will determine if it's a safe choice for you.

Check out this video and blog from Thrive's founder, Katie Lain, as she describes her experience of what it feels like to drink alcohol on naltrexone. Click here to read/watch.

According to the Sinclair Method (TSM) protocol, naltrexone is taken in a targeted dose, one hour before drinking. On non-drinking days, it is not taken. This differs from daily use, where naltrexone is taken every day regardless of drinking, and the dosage may or may not be targeted. Ultimately, how you take naltrexone is a decision for you and your doctor to determine based on your needs and goals.

To learn more about the differences between targeted and daily use, check out this video and blog by our medical advisor, Dr. Joseph Volpicelli: The Sinclair Method vs Daily Naltrexone: What's the Difference?

Yes, naltrexone is a prescription medication, and you’ll need to consult a healthcare provider to determine if it’s appropriate for you. Thrive has partnered with specialized physicians across all 50 states and can provide you with a referral for a naltrexone consult to get started.

If you stop taking naltrexone and drink alcohol, your brain will likely begin to re-learn the connection between drinking and pleasure, potentially undoing progress. It's important to follow the protocol consistently, it's called "the Golden Rule" for a very good reason.

No, naltrexone works differently from Antabuse. It does not cause unpleasant reactions when drinking alcohol but instead reduces cravings and the reward from drinking.

At Thrive, most of our team has personal experience with Alcohol Use Disorder (AUD) and naltrexone, combined with expert knowledge in alcohol reduction strategies. We offer personalized guidance, practical resources, and a compassionate community to help you successfully use naltrexone to achieve your drinking goals and transform your relationship with alcohol.