How to Start The Sinclair Method (TSM): A Step-by-Step Guide

The Sinclair Method (TSM) is a groundbreaking approach to reducing alcohol dependency, using a scientifically backed process called pharmacological extinction. By taking medication before drinking, TSM works to gradually retrain the brain, reducing cravings and allowing people to regain control over their alcohol consumption.

If you're new to TSM and wondering how to get started, this guide will walk you through the exact steps to begin this treatment effectively.

Want a general overview of how TSM works? Click here to read our main guide on The Sinclair Method.

Step 1: Understand the Basics of TSM

Before starting TSM, it’s important to fully understand how it works and why it’s different from traditional abstinence-based approaches.

• TSM uses naltrexone, an FDA-approved medication that blocks the brain’s opioid receptors.
• You only take it before drinking—typically one hour before your first drink of the day.
• Over time, this reduces the pleasure response to alcohol, gradually decreasing cravings and consumption.

Helpful Resources to Learn More About TSM:

• 📖 The Cure for Alcoholism – Dr. Roy Eskapa’s book explaining the science behind TSM
• 🎥 One Little Pill – A documentary featuring real TSM success stories
• 📺 Free video course: Is TSM right for me? 

Step 2: Consult with a Healthcare Professional

To begin TSM, you'll need a prescription for naltrexone. While any doctor can prescribe it, not all are familiar with TSM.

Options for Getting a Prescription:

✔️ Through Your Own Doctor: You may need to bring research showing naltrexone’s effectiveness for alcohol use disorder.
✔️ Through an Online TSM-Specialized Doctor: When you join Thrive, we help connect you with a trusted online physician who understands this treatment.

💰 Click here to see estimated costs for a TSM-friendly doctor and medication. 

Step 3: Get Support for Long-Term Success

While TSM is scientifically proven to work, having the right support system dramatically improves results.

✅ Thrive’s TSM Membership Program offers:

• Private support from TSM-experienced coaches
• A community of peers also using TSM
• Tools to track progress and maintain motivation
• Access to TSM-friendly physicians

📩 Join Thrive today and start TSM with the right support.

Step 4: Start Taking Naltrexone as Directed

Once you have your prescription, it’s time to start TSM!

💊 The Golden Rule of TSM:

• Take one naltrexone pill one hour before drinking.
• No need to take it on non-drinking days.
• Stay consistent—this is a gradual process.

This process rewires your brain’s response to alcohol over time. Without consistent compliance, TSM won’t work effectively.

Step 5: Have Realistic Expectations (This Takes Time!)

TSM isn’t an overnight fix. Research shows that it can take several months to a year to see full results.

📊 Signs TSM is Working:
✔️ Drinking becomes less compulsive
✔️ You experience less craving for alcohol
✔️ You have more alcohol-free days naturally

🔎 Read: 5 Early Signs TSM is Working

 Check out this short video so you understand what to expect with TSM 👇

Step 6: Track Progress and Adjust as Needed

One of the best ways to stay on track is to monitor your drinking patterns and notice gradual changes.

🎯 What to Track on TSM:

• How often you drink
• How much you drink per session
• How you feel before and after drinking
• Changes in cravings

💡 Thrive provides progress tracking tools inside our program to help you see your improvement over time.

Step 7: Build Healthy Habits Alongside TSM

TSM addresses the biological craving for alcohol, but long-term success also comes from building new habits and coping strategies.

💡 People using TSM have the best results when they:
✔️ Find healthy alternatives for stress relief
✔️ Identify new hobbies or interests
✔️ Connect with supportive communities

👥 Thrive offers tools and coaching to help you build new habits.

Step 8: Celebrate Small Wins 🎉

TSM success happens gradually, so acknowledge your progress along the way!

✅ Had a drink and stopped earlier than usual? Celebrate it.
✅ Skipped a drinking day without effort? Recognize it.
✅ Felt less desire to drink? That’s progress!

Inside Thrive, we encourage members to celebrate even the smallest milestones because they add up over time.

Step 9: Reflect, Set Goals, and Keep Moving Forward

As you go through TSM, take time to reflect:
🤔 How has your relationship with alcohol changed?
🎯 What personal goals do you want to work toward?

Some people on TSM simply want to drink less, while others aim for complete abstinence. Whatever your goal, TSM allows you to take control on your terms.

Ready to Start TSM? Here’s Your Next Step…

TSM is a proven and effective way to regain control over drinking, but having the right support is key.

📩 Join Thrive today to start your TSM journey with expert support and guidance.

Medical Disclaimer: The information provided in this article is for educational and informational purposes only and should not be considered medical advice. The Sinclair Method (TSM) and the use of naltrexone should only be pursued under the guidance of a licensed healthcare professional. Do not disregard or delay seeking medical advice based on the information provided here. Always consult a doctor before making any decisions regarding your health or treatment.